Housed in an historic sixteenth century building, the Santo Domingo is decorated with a style in keeping with its rich history and tradition, filled with original artwork and antique furniture throughout. Situated in a quiet Plaza in the heart of Madrid, it is just 200 meters from the Royal Palace. Featuring soft pastel tones, antique-style furnishings and light patterned fabrics, the 120 air conditioned guestrooms have modern amenities including work desks with Internet access, bathroom telephones, cable television, pay movies and minibars.

Spanish and international cuisine is served in the relaxed ambience of the Best Western Premier Santo Domingo restaurant, decorated with warm colors and 17th century paintings. Guests can relax in the lobby with a complimentary newspaper, and plan excursions in the Internet corner or with the help of the multilingual staff at the front desk. For business guests there are conference rooms, as well as banquet facilities. For fitness enthusiasts the hotel provides access to a nearby gymnasium. Visitors to Madrid are surrounded by attractions and art lovers are one kilometer from the major museums including the Prado, home to one of Europe's most renowned art collections. The nearest metro station is Santo Domingo, opposite the hotel. Madrid Barajas Airport is a 20 minute drive and 10 kilometers away. Frequent underground metro services connect the airport with Madrid city center. Taxis are available from the airport and the blue airport bus departs every 15 minutes for the underground bus terminal at Plaza de Colón in central Madrid.
Driving directions: From the airport by car, follow the N-11 highway to Madrid city center/Avenida de America, turn left onto Serrano and continue until Plaza de la Independencia, turning onto Gran Via. Go straight on to Plaza Callao, then turn onto Preciados until Plaza de Santo Domingo where the hotel is located.